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Granzyme B-secreting B cells as a potential cell therapeutic

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Chesneau, Mélanie | Danger, Richard | Le Bot, Sabine | Poulaouec, Cyrielle | Filloux, Matthieu | Saintamand, Alexis | Glaudet, Florence | Dubois, Florian | Durand, Maxim | Jacquemont, Lola | Guerrif, Pierrick | Charreau, Béatrice | Giral, Magali | Cogné, Michel | Degauque, Nicolas | Brouard, Sophie

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International audience. B cells secreting granzyme B (GZMB+) with suppressive properties have been discovered in a growing number of immunological contexts, autoimmunity, chronic infection, and neoplasias, as well as in healthy volunteers under physiological conditions.To date, no phenotype has been proposed for these GZMB+ B cells, and their biology also remains uncharacterized.These data provide new insights into GZMB+ B cell biology and function that emerge as one component of a complex regulatory network. Successfully expanding these cells while maintaining their potent immunosuppressive properties provides new clues for novel future cell therapies.

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