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Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression

Archive ouverte | Marçais, Ambroise | CCSD

International audience. Mutations in TET2, encoding one of the TET members responsible for the conversion of DNA cytosine methylation to hydroxymethylation (5-hmc), have been recently described in Human T-lymphotrop...

Arsenic trioxide (As2O3) as a maintenance therapy for adult T cell leukemia/lymphoma

Archive ouverte | Marçais, Ambroise | CCSD

International audience. Background: Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination o...

KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target

Archive ouverte | Cheminant, Morgane | CCSD

International audience. Adult T-cell leukemia (ATL) is a lymphoid neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1), which encodes the transcriptional activator Tax, which participates in the immortaliz...

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