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The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" micro-environment in patients with adult T-cell leukemia lymphoma

Archive ouverte | Kchour, Ghada | CCSD

International audience

The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma.

Archive ouverte | Kchour, Ghada | CCSD

International audience. BACKGROUND: HTLV-I associated adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis due to chemo-resistance and immuno-compromised micro-environment. The combination of zidovudine a...

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Archive ouverte | Dassouki, Zeina | CCSD

International audience. The human T-cell lymphotropic virus type I (HTLV-1) Tax transactivator initiates transformation in adult T-cell leukemia/lymphoma (ATL), a highly aggressive chemotherapy-resistant malignancy....

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