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Archive ouverte | Pivot, Xavier, B. | CCSD

International audience. BACKGROUND: Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra) is an epot...

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Archive ouverte | Chaigneau, Loïc | CCSD

International audience. The pemetrexed disodium (Alimta), LY231514) is the first antifolate able to inhibit at the same time the synthesis of purins and pyrimidins. Many therapeutic tests were carried out in clinica...

Safety profile of new anticancer drugs.

Archive ouverte | Mansi, Laura | CCSD

International audience. Importance of the field: The development of targeted anticancer therapies stems from advances in molecular biology. New agents range from antibodies that form complexes with antigens on the s...

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