Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

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Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

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Weller, Sandra | Reynaud, Claude-Agnès | Weill, Jean-Claude

International audience. Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. K?rs has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.

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