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Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.

Archive ouverte | Boucharaba, Ahmed | CCSD

The role of lysophosphatidic acid (LPA) in cancer is poorly understood. Here we provide evidence for a role of LPA in the progression of breast cancer bone metastases. LPA receptors LPA(1), LPA(2), and LPA(3) were expressed in hum...

Lysophosphatidic Acid Receptor Type 1 (LPA 1 ) Plays a Functional Role in Osteoclast Differentiation and Bone Resorption Activity

Archive ouverte | David, Marion | CCSD

International audience. Lysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six different G protein-coupled receptors (LPA1–6) with pleiotropic activities on multiple cell types. We have previ...

Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.

Archive ouverte | Simon, Marie Françoise | CCSD

Lysophosphatidic acid (LPA) is a bioactive phospholipid acting via specific G protein-coupled receptors that is synthesized at the extracellular face of adipocytes by a secreted lysophospholipase D (autotaxin). Preadipocytes mainl...

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