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Developing TK databases and tools to support food safety assessment

Archive ouverte | Dorne, Jean-Lou | CCSD

International audience. requirements for pre-market authorisation of pesticides (regulation 283-284/2013) for which comparative in vitro metabolism (rat) human and in vivo rat TK data are required. As a consequence,...

Reconnecting exposure, toxicokinetics and toxicity in food safety : OpenFoodTox and TKplate for human health, animal health and ecological risk assessment

Archive ouverte | Dorne, Jean-Lou | CCSD

International audience. In food safety, sound risk characterisation requires the integration of external dose (oral exposure), internal dose (toxicokinetics (TK) and toxicodynamic (TD) data. Here, a workflow allowin...

Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout

Archive ouverte | Tebby, Cléo | CCSD

International audience. Following outbreaks of feed and food adulterations with a melamine and cyanuric acid mixture in 2007 and melamine in 2008 respectively, the kinetics and toxicodynamics of the mixture have bee...

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