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Regulation and role of calcium in cellular senescence

Archive ouverte | Martin, Nadine | CCSD

International audience. Cellular senescence is a state of stable cell proliferation arrest accompanied by a distinct secretory program impacting the senescent cell microenvironment. This phenotype can be induced by ...

A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression

Archive ouverte | Czarnecka-Herok, Joanna | CCSD

International audience. The ELN gene encodes tropoelastin which is used to generate elastic fibers that insure proper tissue elasticity. Decreased amounts of elastic fibers and/or accumulation of bioactive products ...

MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1 : implications for MYC-induced safeguard mechanisms and cancer

Archive ouverte | Ma, Xingjie | CCSD

ABSTRACT The MYC and NMYC transcription factors (TFs) play a key role in cell proliferation and are overexpressed in most cancer cells. However, in normal cells their overexpression triggers safeguard mechanisms promoting cell dea...

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