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MTM1-mediated production of phosphatidylinositol 5-phosphate fuels the formation of podosome-like protrusions regulating myoblast fusion

Archive ouverte | Mansat, Mélanie | CCSD

International audience. Myogenesis is a multistep process that requires a spatiotemporal regulation of cell events resulting finally in myoblast fusion into multinucleated myotubes. Most major insights into the mech...

PI3KC2β depletion rescues endosomal trafficking defects in Mtm1 knockout skeletal muscle cells

Archive ouverte | Mansat, Mélanie | CCSD

International audience. Phosphoinositides constitute a class of seven phospholipids found in cell membranes, regulating various cellular processes like trafficking and signaling. Mutations in their metabolizing enzy...

Phosphoinositides take a central stage in regulating blood platelet production and function

Archive ouverte | Severin, Sonia | CCSD

International audience. Blood platelets are produced by megakaryocytes through a complex program of differentiation and play a critical role in hemostasis and thrombosis. These anucleate cells are the target of anti...

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