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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Archive ouverte | Ku, Cheng-Lung | CCSD

International audience. Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor...

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

Archive ouverte | Casrouge, Armanda | CCSD

International audience. Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral encephalitis in western countries. Its pathogenesis remains unclear, as it affects otherwise health...

TLR3 deficiency in patients with herpes simplex encephalitis.

Archive ouverte | Zhang, Shen-Ying | CCSD

International audience. Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dom...

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