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A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

Archive ouverte | Barthélemy, Nicolas | CCSD

International audience. Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites...

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

Archive ouverte | Salloway, Stephen | CCSD

International audience. Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes decades before the onset of clinical symptoms, enabling testing of interventions in the asymptomatic and ...

SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

Archive ouverte | Paterson, Ross | CCSD

International audience. Alzheimer disease (AD) is one of several neurodegenerative diseases characterized by dysregulation, misfolding and accumulation of specific proteins in the CNS. The stable isotope labelling k...

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