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Protumoral effect of mesenchymal stromal cells in ovarian cancer by cytokine secretions and activation of the innate immune response. Effets des cellules stromales mésenchymateuses dans la chimiorésistance des cancers ovariens par sécrétion de chimiokines et polarisation des macrophages

Archive ouverte | Le Naour, Augustin | CCSD

Ovarian cancer is the leading cause of gynecological cancer death. To date, the most effective treatment consists of the complete excision of the tumor associated with chemotherapy based on platinum salts and taxanes. However, the...

Role of MSCs in Antitumor Drug Resistance

Archive ouverte | Le Naour, Augustin | CCSD

International audience. Resistance to anticancer drugs is a major problem hindering the treatment of many cancers. The tumor microenvironment can modulate the efficacy of chemotherapy. Among the cells of this microe...

Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance

Archive ouverte | Le Naour, Augustin | CCSD

International audience. Background: Ovarian cancer is associated with poor prognostic outcome due to late diagnosis and to intrinsic and acquired resistance to platinum-based chemotherapy in a large number of patien...

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