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MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development

Archive ouverte | Delbaere, Joke | CCSD

International audience. Inactivating mutations in the human SLC16A2 gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in the Allan–Herndon–Dudley syndrome accompanied by sever...

Characterization of Chicken Thyroid Hormone Transporters

Archive ouverte | Bourgeois, Nele | CCSD

International audience. Thyroid hormone (TH) transmembrane transporters are key regulators of TH availability in target cells where correct TH signaling is essential for normal development. Although the chicken embr...

Deficiency of the Thyroid Hormone Transporter Monocarboxylate Transporter 8 in Neural Progenitors Impairs Cellular Processes Crucial for Early Corticogenesis

Archive ouverte | Vancamp, Pieter | CCSD

International audience. Thyroid hormones (THs) are essential for establishing layered brain structures, a process called corticogenesis, by acting on transcriptional activity of numerous genes. In humans, deficiency...

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