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Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Archive ouverte | Therizols, Gabriel | CCSD

JOBIM 2023 - Journées Ouvertes en Biologie, Informatique et Mathématiques, NIce 2023. International audience. Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-gen...

Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Archive ouverte | Therizols, Gabriel | CCSD

National audience. Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but alsoto non-genomic processes. 5-fluorouracil (5-FU), the most widely used che- motherapy in oncology isass...

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance

Archive ouverte | Therizols, Gabriel | CCSD

Abstract Partial response to chemotherapy leads to disease resurgence. Upon treatment, a subpopulation of cancer cells, called drug-tolerant persistent cells, display a transitory drug tolerance that lead to treatment resistance 1...

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