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Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy

Archive ouverte | Frau, Carla | CCSD

International audience. Abstract Intestinal crypts are composed of heterogeneous and highly plastic cell populations. Lgr5high-stem cells (SC) are responsible for homeostatic renewal, but other cells can revert to a...

Fine resolution clustering of TP53 variants into functional classes predicts cancer risks and spectra among germline variant carriers

Archive ouverte | Montellier, Emilie | CCSD

ABSTRACT Li-Fraumeni syndrome (LFS) is a heterogeneous predisposition to a broad spectrum of cancers caused by pathogenic TP53 germline variants. We have used a clustering approach to assign missense variants to functional classes...

Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome

Archive ouverte | Montellier, Emilie | CCSD

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