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LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice

Archive ouverte | Latour, Alizee | CCSD

International audience. Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to in...

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

Archive ouverte | Souchet, Benoit | CCSD

International audience. Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by dr...

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models

Archive ouverte | Souchet, Benoit | CCSD

International audience. Down syndrome is a common genetic disorder caused by trisomy of chromosome 21. Brain development in affected foetuses might be improved through prenatal treatment. One potential target is DYR...

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