Diagnosing plague in 17th century camelids from Romania: unmasking role of camelids in plague dissemination along historical Silk Routes

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Hama, Hamadou, Oumarou | Boualam, Mahmoud | Armengaud, Jean | Drancourt, Michel | Aboudharam, Gérard | Bălășescu, Adrian | Radu, Valentin

Edité par CCSD ; Oxford University Press -

International audience. Six camels (R01-R06) exhumed from a 17th century Silk Route site in Agighiol, Romania, along with negative controls, were blindly investigated via dental pulp paleometagenomics and paleoproteomics for traces of Yersinia pseudotuberculosis complex including the plague agent Yersinia pestis. Sample R04 yielded a 32 bp read specific for the Y. pseudotuberculosis complex valine-tRNA ligase gene; sample R05 yielded a 30 bp and a 33 bp reads specific for the Y. pseudotuberculosis complex. Further, samples R04 and R05 yielded a 16S rRNA guanine transferase specific for Y. pestis and one other Y. pseudotuberculosis complex peptide. Taken together, these validated data diagnosed plague in these ancient camels which likely participated in plague dissemination along ancient Silk Routes during the large Medieval and Modern Times pandemic in Europe. . Six chameaux (R01-R06) exhumés d'un site de la Route de la Soie du XVIIe siècle à Agighiol, en Roumanie, ainsi que des témoins négatifs, ont été étudiés en aveugle par paléométagénome et paléoprotéomique de la pulpe dentaire à la recherche de traces du complexe Yersinia pseudotuberculosis, dont l'agent de la peste Yersinia pestis. L'échantillon R04 a fourni une lecture de 32 pb spécifique du gène de la valine-ARNt ligase du complexe Y. pseudotuberculosis ; l'échantillon R05 a fourni des lectures de 30 pb et 33 pb spécifiques du complexe Y. pseudotuberculosis. De plus, les échantillons R04 et R05 ont fourni une 16S ARNr guanine transférase spécifique de Y. pestis et un autre peptide du complexe Y. pseudotuberculosis. Prises ensemble, ces données validées ont permis de diagnostiquer la peste chez ces chameaux anciens, qui ont probablement participé à sa dissémination le long des anciennes Routes de la Soie lors de la grande pandémie médiévale et moderne en Europe.

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