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Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC

Archive ouverte | Figarol, Sarah | CCSD

Drug-tolerant "dormant" cells (DTC) have emerged as one of the major non-genetic mechanisms driving resistance to targeted therapy in lung cancer, although the sequence of events leading to entry and exit from dormancy remain poor...

Abstract LB080: Tipifarnib prevents emergence of resistance to osimertinib in EGFR-mutant NSCLC

Archive ouverte | Figarol, Sarah | CCSD

International audience. Abstract Purpose: Drug-tolerant “dormant” cells (DTC) have emerged as one of the major non-genetic mechanisms driving resistance to targeted therapy in lung cancer, although the sequence of e...

Uncovering phenotypic heterogeneity of drug-tolerance in EGFR-mutated non-small cell lung cancer in vivo and in patients

Archive ouverte | Delahaye, Célia | CCSD

International audience. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are effective therapies for advanced lung cancer patients bearing EGFR-activating mutations but are not curative due to ...

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