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The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells

Archive ouverte | Cataldo, Luis Rodrigo | CCSD

International audience. The amplification of glucose-stimulated insulin secretion (GSIS) through incretin signaling is critical for maintaining physiological glucose levels. Incretins, like glucagon-like peptide 1 (...

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Archive ouverte | Blanchi, Bruno | CCSD

International audience. Objectives: Readily accessible human pancreatic beta cells that are functionally close to primary adult beta cells are a crucial model to better understand human beta cell physiology and deve...

HOXB6 and HOXB8 control immune-cancer cell interactions in pancreatic cancer

Archive ouverte | Bertonnier-Brouty, Ludivine | CCSD

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. Transcriptomic analysis comparing human embryonic and PDAC tissue identified a large overlap of exp...

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