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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

Archive ouverte | Labaronne, Emmanuel | CCSD

International audience. Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus that relies on alternative splicing, translational, and post-translational mechanisms to produce over 15 functional protein...

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

Archive ouverte | Labaronne, Emmanuel | CCSD

Abstract Human immunodeficiency virus type-1 (HIV-1) is a complex retrovirus which relies on alternative splicing, translational and post-translational mechanisms to produce more than 15 functional proteins from its single ∼10kb t...

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Archive ouverte | Bertrand, Lisa | CCSD

International audience. The development of ribosomal profiling (Riboseq) revealed the immense coding capacity of human and viral genomes. Here, we used Riboseq to delineate the translatome of HIV-1 in infected CD4+ ...

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