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Tuberculosis Exacerbates HIV-1 infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages

Archive ouverte | Souriant, Shanti | CCSD

International audience. The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using ...

Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis

Archive ouverte | Lastrucci, Claire | CCSD

International audience

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

Archive ouverte | Dupont, Maeva | CCSD

International audience. While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1...

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