miR-223: An inflammatory oncomiR enters the cardiovascular field

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Taïbi, Fatiha | Metzinger-Le Meuth, Valérie | Massy, Ziad | Metzinger, Laurent

Edité par CCSD ; Elsevier -

International audience. MicroRNAs (miRNAs) are small, noncoding RNAs of 18–22 nucleotides in length that regulate post-transcriptional expression by base-pairing with target mRNAs. It is now clearly established that miRNAs are involved in most of the cell's physiopathological processes (including carcinogenesis and metabolic disorders). This review focuses on miR-223, which was first described as a modulator of hematopoietic lineage differentiation. We outline the role of miR-223 deregulation in several types of cancers and highlight its inclusion in a newly identified and fast-growing family of miRNAs called oncomiRs. We then look at miR-223's emerging role in inflammatory and metabolic disorders, with a particular focus on muscle diseases, type II diabetes, atherosclerosis and vascular calcification. miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field.

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