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Current Advances in Gene Therapies of Genetic Auditory Neuropathy Spectrum Disorder

Archive ouverte | Saidia, Anissa Rym | CCSD

International audience. Auditory neuropathy spectrum disorder (ANSD) refers to a range of hearing impairments characterized by an impaired transmission of sound from the cochlea to the brain. This defect can be due ...

Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening

Archive ouverte | Saidia, Anissa, Rym | CCSD

International audience. The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed earl...

The human OPA1 delTTAG mutation induces adult onset and progressive auditory neuropathy in mice

Archive ouverte | Affortit, Corentin | CCSD

International audience. Dominant optic atrophy (DOA) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by heterozygous variants in OPA1, encoding a mitochondrial dynamin-relate...

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