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Effects of tACS-induced phase entrainment in cortical neuronal models
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Edité par CCSD -
International audience. In this study, we used two complementary types of realistic models – detailed and simplified based on the Hodgkin–Huxley (HH) formalism – to investigate the phase entrainment of neocortical cell types during transcranial alternating current stimulation (tACS). Our objective using this dual-model approach was two-fold: first, understanding further cell-specific frequency responses to tACS, thereby improving stimulation design for targeted cellular stimulation; and second, facilitating comparisons between detailed and simplified models. The latter are particularly valuable for fast computation and network modeling, especially to characterize how low-magnitude electric field effects on entire networks.Our results reveal that Layer 5 pyramidal cells exhibit low-pass filter behavior, showing a type of frequency-dependent entrainment. In contrast, GABAergic interneurons (bipolar, BP; parvalbumin, PV; and somatostatin, SST) demonstrate different resonant frequencies, suggesting the potential for selective targeting of specific neuronal types through frequency targeting. The study also finds that vasoactive intestinal peptide interneurons do not show reliable entrainment, underscoring the importance of input-dependent entrainment.Notably, both detailed and simplified models showed similar responses to electrical field, with entrainment increasing linearly with electrical field amplitude. This consistency between models suggests the potential for using simplified models in broader network studies, given their lower computational demands and realistic cell response replication. Overall, our results highlight the nuanced interactions between tACS and different neuronal types, emphasizing the need for considering both cell-specific responses and network dynamics in future research.
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