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Exploring hormones and antibiotics in soils of Crohn's disease clusters in Northern France
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Edité par CCSD -
International audience. Crohn's disease (CD), a chronic inflammatory disease, has no known etiology, however, environmental exposures are suspected. The exposure from soil pollution is not examined, despite its various exposures to humans by ingestion, inhalation, and contact. This research will explore the characteristics of soils in predefined CD clusters in Northern France, identify soil pollutants and compare them between high- and low-incidence clusters. Contaminants in soil were interpreted based on a national data base called RMQS on soil quality. It showed a higher concentration then national background for Arsenic, Chromium and Lead in clusters of high-incidence, with a concentration of 11, 50.03 and 32.51mg/kg respectively. These results appeared to be consistent with a study on CD, which showed high concentrations of lead and chromium in the baby teeth of patients. Concentration of all heavy metals in clusters of high-incidence were higher than low-incidence clusters and showed a correlation of p=0.557 with the relative risk of the disease. With the need to explore all contaminants in soils and a scarcity in existing data on soil, a sampling campaign was done in all clusters of CD, examining the presence of metals, hydrocarbures, benzenes, polychlorobiphényles in addition to a list of pharmaceuticals including 17α-estradiol, 17β-estradiol, estrone, estriol, and 17α-ethinylestradiol, ibuprofen, bisphenol A, paracetamol, carbamazepine, penicillin G, Roxithromycine, sulfadiazine and testosterone. The results of this campaign will allow further research by epidemiologists. The presence of these elements in soils is studied for the first time in relation to CD and soils on a large-scale map.
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