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Extending the chemical space of enzymes through genetic code expansion

Archive ouverte | Vernhes, Emeline | CCSD

International audience. The incorporation into proteins of non-canonical amino acids is a powerful way tosurmount the limited chemical diversity of natural amino acids.1 Advantageously, thisapproach provides a means...

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Archive ouverte | Vernhes, Emeline | CCSD

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Archive ouverte | Vernhes, Emeline | CCSD

International audience. Standard enzyme engineering strategies relies on one or several amino acids permutations among the 20 amino acids (AA). The natural AA repertoire displays only limited chemical functions, whi...

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