Platelets Are Critical Key Players in Sepsis

Archive ouverte

Vardon-Bounes, Fanny | Ruiz, Stéphanie | Gratacap, Marie-Pierre | Garcia, Cedric | Payrastre, Bernard | Minville, Vincent

Edité par CCSD ; MDPI -

International audience. Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet–pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion