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The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

Archive ouverte | Maison, Christèle | CCSD

International audience. SUMOylation promotes targeting of HP1α to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1α accumulation at this locatio...

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.

Archive ouverte | Maison, Christèle | CCSD

International audience. HP1 enrichment at pericentric heterochromatin is considered important for centromere function. Although HP1 binding to H3K9me3 can explain its accumulation at pericentric heterochromatin, how...

The methyltransferase Suv39h1 links the SUMO pathway to HP1a marking at pericentric heterochromatin

Archive ouverte | Maison, Christèle | CCSD

International audience. The trimethylation of histone H3 on lysine 9 (H3K9me3) – a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) – has provided a basis for the reader/writer mode...

Chargement des enrichissements...