Development of circulating isolates of Plasmodium falciparum is accelerated in Anopheles vectors with reduced reproductive output

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Werling, Kristine | Itoe, Maurice | Shaw, W. Robert | Hien, Raymond Dombagniro | Bazié, Bali Jean | Fofana, Aminata | Adams, Kelsey | Ouattara, Bienvenu Seydou | Sanou, Mathias | Peng, Duo | Dabiré, Roch Kounbobr | Da, Dari | Yerbanga, Rakiswendé Serge | Diabaté, Abdoulaye | Lefèvre, Thierry | Catteruccia, Flaminia

Edité par CCSD ; Public Library of Science -

International audience. Anopheles gambiae and its sibling species Anopheles coluzzii are the most efficient vectors of the malaria parasite Plasmodium falciparum . When females of these species feed on an infected human host, oogenesis and parasite development proceed concurrently, but interactions between these processes are not fully understood. Using multiple natural P . falciparum isolates from Burkina Faso, we show that in both vectors, impairing steroid hormone signaling to disrupt oogenesis leads to accelerated oocyst growth and in a manner that appears to depend on both parasite and mosquito genotype. Consistently, we find that egg numbers are negatively linked to oocyst size, a metric for the rate of oocyst development. Oocyst growth rates are also strongly accelerated in females that are in a pre-gravid state, i.e. that fail to develop eggs after an initial blood meal. Overall, these findings advance our understanding of mosquito-parasite interactions that influence P . falciparum development in malaria-endemic regions.

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