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Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

Archive ouverte | Cougnoux, Antony | CCSD

International audience. Background Escherichia coli strains harbouring the pks island (pks+ E. coli) are often seen in human colorectal tumours and have a carcinogenic effect independent of inflammation in an AOM/IL...

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Archive ouverte | Dalmasso, Guillaume | CCSD

International audience. Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senesce...

Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence

Archive ouverte | Dalmasso, Guillaume | CCSD

International audience

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