Gonadotropin and thyrostimulin receptors

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Misrahi, Micheline | de Roux, Nicolas | Ghinea, Nicolae | Beau, Isabelle | Loosfelt, Hugues | Vannier, Brigitte | Savouret, Jean-François | Milgrom, Edwin

Edité par CCSD ; Pharmakon-Press (Athènes, Grèce) [1987-....] -

International audience. Gonadotropin and thyrostimulin receptors belong to a subgroup of G-protein coupled receptors characterized by a large extracellular domain responsible for the binding of the hormone. Soluble receptors arise from premessenger RNA alternative splicing (LH receptor) or cleavage and shedding of the ectodomain (TSH receptor). FSH and TSH receptors are restricted to the basolateral domain of their target cells. These receptors are also present in endothelial celts of target organ vessels and are involved in hormone transcytosis. Various genetic abnormalities of these receptors have been described.

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