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Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD

Archive ouverte | Johanns, Manuel | CCSD

International audience

Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD

Archive ouverte | Johanns, Manuel | CCSD

International audience. Background and aims: Liver homeostasis is ensured in part by time-of-day-dependent processes, many of them being paced by the molecular circadian clock. Liver functions are compromised in met...

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Archive ouverte | Bobowski-Gerard, Marie | CCSD

International audience. Abstract Tissue injury triggers activation of mesenchymal lineage cells into wound-repairing myofibroblasts, whose unrestrained activity leads to fibrosis. Although this process is largely co...

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