Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study
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Lengelé, Laetitia | Rolland, Yves | Martinez, Laurent | Gillette-Guyonnet, Sophie | Parini, Angelo | Lucas, Alexandre | Vellas, Bruno | Barreto de Souto, Philipe | Carrié, Isabelle | Brigitte, Lauréane | Faisant, Catherine | Lala, Françoise | Delrieu, Julien | Villars, Hélène | Combrouze, Emeline | Badufle, Carole | Zueras, Audrey | Andrieu, Sandrine | Cantet, Christelle | Morin, Christophe | van Kan, Gabor Abellan | Dupuy, Charlotte | Caillaud, Céline | Ousset, Pierre-Jean | Willis, Sherry | Belleville, Sylvie | Gilbert, Brigitte | Fontaine, Francine | Dartigues, Jean-François | Marcet, Isabelle | Delva, Fleur | Foubert, Alexandra | Cerda, Sandrine | Costes, Corinne | Rouaud, Olivier | Manckoundia, Patrick | Quipourt, Valérie | Marilier, Sophie | Franon, Evelyne | Bories, Lawrence | Pader, Marie-Laure | Basset, Marie-France | Lapoujade, Bruno | Faure, Valérie | Tong, Michael Li Yung | Malick-Loiseau, Christine | Cazaban-Campistron, Evelyne | Desclaux, Françoise | Blatge, Colette | Dantoine, Thierry | Laubarie-Mouret, Cécile | Saulnier, Isabelle | Clément, Jean-Pierre | Picat, Marie-Agnès | Bernard-Bourzeix, Laurence | Willebois, Stéphanie | Désormais, Iléana | Cardinaud, Noëlle | Bonnefoy, Marc | Livet, Pierre | Rebaudet, Pascale | Gédéon, Claire | Burdet, Catherine | Terracol, Flavien | Pesce, Alain | Roth, Stéphanie | Chaillou, Sylvie | Louchart, Sandrine | Sudres, Kristelle | Lebrun, Nicolas | Barro-Belaygues, Nadège | Touchon, Jacques | Bennys, Karim | Gabelle, Audrey | Romano, Aurélia | Touati, Lynda | Marelli, Cécilia | Pays, Cécile | Robert, Philippe | Le Duff, Franck | Gervais, Claire | Gonfrier, Sébastien | Gasnier, Yannick | Bordes, Serge | Begorre, Danièle | Carpuat, Christian | Khales, Khaled | Lefebvre, Jean-François | El Idrissi, Samira Misbah | Skolil, Pierre | Salles, Jean-Pierre | Dufouil, Carole | Lehéricy, Stéphane | Chupin, Marie | Mangin, Jean-François | Bouhayia, Ali | Allard, Michèle | Ricolfi, Frédéric | Dubois, Dominique | Martel, Marie Paule Bonceour | Cotton, François | Bonafé, Alain | Chanalet, Stéphane | Hugon, Françoise | Bonneville, Fabrice | Cognard, Christophe | Chollet, François | Payoux, Pierre | Voisin, Thierry | Peiffer, Sophie | Hitzel, Anne | Zanca, Michel | Monteil, Jacques | Darcourt, Jacques | Molinier, Laurent | Derumeaux, Hélène | Costa, Nadège | Perret, Bertrand | Vinel, Claire | Caspar-Bauguil, Sylvie | Olivier-Abbal, Pascale | Coley, Nicola
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CCSD ; Oxford University Press / The Gerontological Society of America -
International audience.
Background: Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study.Methods: IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored.Results: Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes.Conclusions: GDF-15 plasma levels were related to key malnutrition criteria.
