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Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

Archive ouverte | Di Buduo, Christian | CCSD

International audience. Thrombocytopenic disorders have been treated with the Thrombopoietin-receptor agonist Eltrombopag. Patients with the same apparent form of thrombocytopenia may respond differently to the trea...

Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome

Archive ouverte | Lordier, Larissa | CCSD

International audience. Bernard Soulier Syndrome (BSS) is a severe bleeding disorder with moderate to severe thrombocytopenia, giant platelets, and platelet dysfunction, caused by biallelic mutations in GP1BA, GP1BB...

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

Archive ouverte | Basso-Valentina, Francesca | CCSD

International audience. Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition to leukemia. Some pat...

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