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Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors

Archive ouverte | Flipo, Marion | CCSD

International audience. Summary In many streptococci, competence for natural DNA transformation is regulated by the Rgg ‐type regulator ComR and the pheromone ComS , which is sensed intracellularly. We compared the ...

Ethionamide Boosters: Synthesis, Biological Activity, and Structure−Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors

Archive ouverte | Flipo, Marion | CCSD

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Archive ouverte | Carette, Xavier | CCSD

International audience. Ethionamide is an antituberculous drug for the treatment of multidrug-resistant Mycobacterium tuberculosis. This antibiotic requires activation by the monooxygenase EthA to exert its activity...

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