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Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms

Archive ouverte | Pegliasco, Jean | CCSD

International audience. Mutations in the calreticulin ( CALR ) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the...

Therapy Related Myeloid Neoplasm Post PARP Inhibitors: Potential Clonal Selection.

Archive ouverte | Martin, Jean-Edouard | CCSD

International audience. Introduction Clonal selection is one of the mechanisms leading to therapy-related myeloid neoplasms (TRMN). A preexisting somatic mutation in hematopoietic stem cell (defined as clonal hemato...

Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers

Archive ouverte | Khalife-Hachem, Sabine | CCSD

International audience. Definition of therapy-related myeloid neoplasms (TRMN) is only based on clinical history of exposure to leukemogenic therapy. No specific molecular classification combining therapy-related ac...

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