Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study)
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Giudici, Kelly | Guyonnet, Sophie | Rolland, Yves | Vellas, Bruno | de Souto Barreto, Philipe | Nourhashemi, Fati | Carrié, Isabelle | Brigitte, Lauréane | Faisant, Catherine | Lala, Françoise | Delrieu, Julien | Villars, Hélène | Combrouze, Emeline | Badufle, Carole | Zueras, Audrey | Andrieu, Sandrine | Cantet, Christelle | Morin, Christophe | Kan, Gabor Abellan Van | Dupuy, Charlotte | Caillaud, Céline | Ousset, Pierre-Jean | Willis, Sherry | Belleville, Sylvie | Gilbert, Brigitte | Fontaine, Francine | Dartigues, Jean-François | Marcet, Isabelle | Delva, Fleur | Foubert, Alexandra | Cerda, Sandrine | Costes, Corinne | Rouaud, Olivier | Manckoundia, Patrick | Quipourt, Valérie | Marilier, Sophie | Franon, Evelyne | Bories, Lawrence | Pader, Marie-Laure | Basset, Marie-France | Lapoujade, Bruno | Faure, Valérie | Tong, Michael Li Yung | Malick-Loiseau, Christine | Cazaban-Campistron, Evelyne | Desclaux, Françoise | Blatge, Colette | Dantoine, Thierry | Laubarie-Mouret, Cécile | Saulnier, Isabelle | Clément, Jean-Pierre | Picat, Marie-Agnès | Bernard-Bourzeix, Laurence | Willebois, Stéphanie | Désormais, Iléana | Livet, Pierre | Rebaudet, Pascale | Gédéon, Claire | Burdet, Catherine | Terracol, Flavien | Pesce, Alain | Roth, Stéphanie | Chaillou, Sylvie | Louchart, Sandrine | Sudres, Kristelle | Lebrun, Nicolas | Bennys, Karim | Gabelle, Audrey | Romano, Aurélia | Touati, Lynda | Marelli, Cécilia | Duff, Franck Le | Gervais, Claire | Gonfrier, Sébastien | Gasnier, Yannick | Bordes, Serge | Begorre, Danièle | Carpuat, Christian | Khales, Khaled | Lefebvre, Jean-François | Idrissi, Samira Misbah El | Skolil, Pierre | Salles, Jean-Pierre | Dufouil, Carole | Lehéricy, Stéphane | Chupin, Marie | Mangin, Jean-François | Hugon, Françoise | Bonneville, Fabrice | Cognard, Christophe | Chollet, François | Payoux, Pierre | Voisin, Thierry | Peiffer, Sophie | Hitzel, Anne | Allard, Michèle | Zanca, Michel | Monteil, Jacques | Darcourt, Jacques | Molinier, Laurent | Derumeaux, Hélène | Costa, Nadège | Perret, Bertrand | Vinel, Claire | Caspar-Bauguil, Sylvie | Olivier-Abbal, Pascale | Coley, Nicola
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CCSD ; MDPI -
International audience.
This study aimed to analyze associations between weight variation patterns and changes in cognitive function and hippocampal volume among non-demented, community-dwelling elderly. Sample was formed of 1394 adults >70 years (63.9% female), all volunteers from the Multidomain Alzheimer Preventive Trial (MAPT). Weight loss was defined as ≥5% of body weight decrease in the first year of follow-up; weight gain as ≥5% of weight increase; and stability if <5% weight variation. Cognition was examined by a Z-score combining four tests. Measures were assessed at baseline, 6, 12, 24, 36, 48, and 60 months of follow-up. Hippocampal volume was evaluated with magnetic resonance imaging in 349 subjects in the first year and at 36 months. Mixed models were performed. From the 1394 participants, 5.5% (n = 76) presented weight loss, and 9.0% (n = 125) presented weight gain. Cognitive Z-score decreased among all groups after 5 years, but decline was more pronounced among those who presented weight loss (adjusted between-group mean difference vs. stable: −0.24, 95%CI: −0.41 to −0.07; p = 0.006). After 3 years, hippocampal atrophy was observed among all groups, but no between-group differences were found. In conclusion, weight loss ≥5% in the first year predicted higher cognitive decline over a 5 year follow-up among community-dwelling elderly, independently of body mass index.
