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Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling

Archive ouverte | Xue, Jian-Bin | CCSD

International audience. Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma membrane...

Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome

Archive ouverte | Montnach, Jérôme | CCSD

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Mineralocorticoid Receptor Antagonism Prevents the Electrical Remodeling That Precedes Cellular Hypertrophy After Myocardial Infarction

Archive ouverte | Perrier, Emeline | CCSD

International audience. Background— Cardiac hypertrophy underlies arrhythmias and sudden death, for which mineralocorticoid receptor (MR) activity has recently been implicated. We sought to establish the sequence of...

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