GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles

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Pozzorini, Christian | Andre, Gregoire | Coletta, Tommaso | Buisson, Adrien | Bieler, Jonathan | Ferrer, Loïc | Kempfer, Rieke | Saintigny, Pierre | Harlé, Alexandre | Vacirca, Davide | Barberis, Massimo | Gilson, Pauline | Roma, Cristin | Saitta, Alexandra | Smith, Ewan | Consales Barras, Floriane | Ripol, Lucia | Fritzsche, Martin | Marques, Ana, Claudia | Alkodsi, Amjad | Marin, Ray | Normanno, Nicola | Grimm, Christoph | Müllauer, Leonhard | Harter, Philipp | Pignata, Sandro | Gonzalez-Martin, Antonio | Denison, Ursula | Fujiwara, Keiichi | Vergote, Ignace | Colombo, Nicoletta | Willig, Adrian | Pujade-Lauraine, Eric | Just, Pierre-Alexandre | Ray-Coquard, Isabelle | Xu, Zhenyu

Edité par CCSD ; Cell Press -

International audience. Highlights d Implementation hurdles restrict adoption of HRD testing, a PARPi response biomarker d GIInger leverages HRD-induced genome scarring from lowcoverage sequencing data d GIInger accurately stratifies ovarian cancer patients for PARPi treatment d GIInger is cost effective and seamlessly integrates into BRCA status workflows Authors

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