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High expression of both mutant and wild-type alleles of c-kit in gastrointestinal stromal tumors

Archive ouverte | Théou, Nathalie | CCSD

International audience

KIT overexpression and amplification in gastrointestinal stromal tumors (GISTs)

Archive ouverte | Tabone, Séverine | CCSD

International audience

KIT mutations induce intracellular retention and activation of an immature form of the KIT protein in gastrointestinal stromal tumors.

Archive ouverte | Tabone-Eglinger, Séverine | CCSD

International audience. PURPOSE: Gastrointestinal stromal tumors (GIST) are frequently associated with gain-of-function mutations of KIT, which can be inhibited by imatinib both in vitro and in vivo. The survival of...

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