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Cellular development and evolution of the mammalian cerebellum

Archive ouverte | Sepp, Mari | CCSD

The expansion of the neocortex, one of the hallmarks of mammalian evolution 1,2 , was accompanied by an increase in the number of cerebellar neurons 3 . However, little is known about the evolution of the cellular programs underly...

Mapping pediatric brain tumors to their origins in the developing cerebellum

Archive ouverte | Okonechnikov, Konstantin | CCSD

Understanding the cellular origins of childhood brain tumors is key for discovering novel tumor-specific therapeutic targets. Previous strategies mapping cellular origins typically involved comparing human tumors to murine embryon...

Mapping pediatric brain tumors to their origins in the developing cerebellum

Archive ouverte | Okonechnikov, Konstantin | CCSD

International audience. Background Distinguishing the cellular origins of childhood brain tumors is key for understanding tumor initiation and identifying lineage-restricted, tumor-specific therapeutic targets. Prev...

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