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Pipecolate and taurine, rat urinary biomarkers for lysine and threonine deficiency

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Azzout-Marniche, Dalila | Moro, Joanna | Roisné-Hamelin, Gaëtan | Khodorova, Nadezda | Rutledge, Douglas, N | Martin, Jean-Charles | Barbillon, Pierre | Tomé, Daniel | Gaudichon, Claire | Tardivel, Catherine | Jouan-Rimbaud Bouveresse, Delphine

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International audience. Pipecolate and taurine, rat urinary biomarkers for lysine and threonine deficiency Materiel and Methods Chemometric Analysis LC-MS Discriminant Component Mass Spectra 24h urine Portal and vena cava plasma 15 % 170% Lysine deficiency Threonine deficiency Biomarker Detection 3 weeks The quality of dietary protein sources became a particularly sensitive issue in the current debates on a rebalancing between animal and plant food sources. The ability of a protein to meet the nutritional requirements of essential amino acids (EAA) is the basis for assessing the quality of protein. The objective of this study was to develop metabolomic approaches to identify specific biomarkers for an EAA deficiency, such as lysine and threonine.

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