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Highly Conserved gsc1 Gene of Pneumocystis jirovecii in Patients with or without Prior Exposure to Echinocandins

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Bonnet, Pierre | Le Gal, Solène | Hoffmann, Claire | Morio, Florent | Diabira, Fouleymata | de Quélen, Athéna | Curral, Guillaume | Negri, Steven | Cogulet, Virginie | Huon, Jean-François | Grégoire, Matthieu | Papon, Nicolas | Le Pape, Patrice | Bouchara, Jean-Philippe | Nevez, Gilles

Edité par CCSD ; American Society for Microbiology -

International audience. Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta- d -glucan, a cell wall component of most fungi, including Pneumocystis spp. Echinocandins are widely used for treating systemic candidiasis and rarely used for treating Pneumocystis pneumonia.

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