Afficher la couverture 'High PDL1/PDL2 gene expression correlates with worse outcome in primary mediastinal large B-cell lymphoma | Camus, Vincent' en grand format
/5

0 avis

High PDL1/PDL2 gene expression correlates with worse outcome in primary mediastinal large B-cell lymphoma

Archive ouverte

Camus, Vincent | Viailly, Pierre-Julien | Drieux, Fanny | Veresezan, Elena-Liana | Sesques, Pierre | Haioun, Corinne | Durot, Eric | Patey, Martine | Rossi, Cédric | Martin, Laurent | Rainville, Vinciane | Bohers, Elodie | Ruminy, Philippe | Penther, Dominique | Kaltenbach, Sophie | Bruneau, Julie | Paillassa, Jérôme | Tournilhac, Olivier | Willaume, Alexandre | Antier, Chloe | Lazarovici, Julien | Leveque, Emilie | Decazes, Pierre | Becker, Stéphanie | Tonnelet, David | Berriolo-Riedinger, Alina | Gaulard, Philippe | Tilly, Herve | Molina, Thierry Jo | Traverse-Glehen, Alexandra | Jardin, Fabrice

Edité par CCSD ; The American Society of Hematology -

International audience. Primary mediastinal B-cell lymphoma (PMBL) is an uncommon entity of aggressive large B-cell lymphoma with an unusually good prognosis, except for 10-15% of chemorefractory cases with poor outcomes. To identify patients at high risk of chemorefractoriness, we performed molecular characterization of a retrospective multicenter cohort of PMBL patients treated with first-line immunochemotherapy. The traits of the patients with gene-expression profiling (GEP) data (n=120) were as follows: median [range] age of 34 [18-67] years, female sex 58.3%, elevated LDH 82.5%, ECOG 0-1 85.7%, Ann Arbor stage I-II 55%, IPI 1-2 64.4%, and median metabolic tumor volume 290.4 [15.7-1147.5] cm3. Among all 137 markers tested for correlation with survival data, only PDL1 and PDL2 expression showed a prognostic impact. Overall, both PDL1 and PDL2 genes were highly expressed in 37 (30.8%) patients (PDL1high/PDL2high; cutoff: median expression of each gene: PDL1 = 0.402, PDL2 = 9.147). The baseline clinical characteristics of PDL1high/PDL2high patients were similar to those of other patients. In univariate analysis, PDL1high/PDL2high status was associated with poor PFS (HR=4.292, 95% CI [1.447-12.817]) and OS (HR=8.24 [1.71-39.7]). In multivariate analysis, PDL1high/PDL2high status was an independent prognostic factor of adverse outcomes (PFS: HR= 5.22 [1.352-20.168], OS: HR= 10.368 [1.204-89.267]). We validated these results in an independent cohort of 40 patients and confirmed the significant association between PDL1high/PDL2high status and inferior PFS (HR=6.11 [1.61-23.2]). High PDL1/PDL2 gene expression defines a population with strong immune privilege and poor outcomes from standard chemotherapy who might benefit from first-line anti-PD1 immunotherapy.

Suggestions

Du même auteur

Identification of primary mediastinal B-cell lymphomas with higher clonal dominance and poorer outcome using 5' RACE

Archive ouverte | Camus, Vincent | CCSD

International audience. Few data exist regarding the tumor B-cell receptor (BCR) repertoire and lymphoid microenvironment in primary mediastinal B-cell lymphoma (PMBL). We applied 5' rapid amplification of cDNA ends...

Outcomes after first-line immunochemotherapy for primary mediastinal B-cell lymphoma: a LYSA study

Archive ouverte | Camus, Vincent | CCSD

International audience. Abstract Primary mediastinal B-cell lymphoma (PMBL) is a rare type of aggressive lymphoma typically affecting young female patients. The first-line standard of care remains debated. We perfor...

Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines

Archive ouverte | Renaud, Loïc | CCSD

International audience. Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive natur...

Chargement des enrichissements...