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Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus. Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus: Interferon genes loss sensitizes tumor cells to viral lysis

Archive ouverte | Delaunay, Tiphaine | CCSD

International audience. Oncolytic immunotherapy is based on the use of non-pathogenic replicative oncolytic viruses (OV) that infect and kill exclusively tumor cells. Recently, we showed that the spontaneous oncolyt...

Reply to: Oncolytic Viral Therapy for Malignant Pleural Mesothelioma

Archive ouverte | Jean, Didier | CCSD

International audience

Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response

Archive ouverte | Achard, Carole | CCSD

International audience. Attenuated measles virus (MV) is currently being evaluated as an oncolytic virus in clinical trials and could represent a new therapeutic approach for malignant pleural mesothelioma (MPM). He...

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