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Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey

Archive ouverte | Barrière, David André | CCSD

International audience. Background and Purpose We previously demonstrated that paracetamol has to be metabolised in the brain by fatty acid amide hydrolase enzyme into AM404 (N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosa...

Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization

Archive ouverte | Barrière, David André | CCSD

International audience. Diabetes comorbidities include disabling peripheral neuropathy (DPN) and an increased risk of developing cancer. Antimitotic drugs, such as paclitaxel, are well known to facilitate the occurr...

Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey

Archive ouverte | Mallet, Christophe | CCSD

International audience

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