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Archive ouverte | Breuil, Louise | CCSD

International audience. [11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are...

P-glycoprotein (ABCB1) inhibits the influx and increases the efflux of $^{11}$C-metoclopramide across the blood-brain barrier: a PET study on non-human primates

Archive ouverte | Auvity, Sylvain | CCSD

International audience. Rationale: PET imaging using radiolabeled high-affinity substrates of P-glycoprotein (ABCB1) has convincingly revealed the role of this major efflux transporter in limiting the influx of its ...

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Archive ouverte | Breuil, Louise | CCSD

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