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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Archive ouverte | Gay, Denise | CCSD

International audience. Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair respons...

Macrophage production and activation are dependent on TRIM33

Archive ouverte | Gallouet, Anne-Sophie | CCSD

The tripartite motif (TRIM) family of proteins plays important roles in innate immunity and antimicrobial infection. None of these proteins has been shown to directly regulate transcription of genes in monocyte/macrophage except T...

Adult hematopoiesis is regulated by TIF1gamma, a repressor of TAL1 and PU.1 transcriptional activity

Archive ouverte | Kusy, Sophie | CCSD

Crosstalk between transcription factors and cytokines precisely regulates tissue homeostasis. Transcriptional intermediary factor 1gamma (TIF1gamma) regulates vertebrate hematopoietic development, can control transcription elongat...

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