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Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer

Archive ouverte | Cassier, Philippe | CCSD

International audience. Netrin-1 is upregulated in cancers as a protumoural mechanism1. Here we describe netrin-1 upregulation in a majority of human endometrial carcinomas (ECs) and demonstrate that netrin-1 blocka...

Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer

Archive ouverte | Cassier, Philippe | CCSD

International audience. Abstract Netrin-1 is upregulated in cancers as a protumoural mechanism 1 . Here we describe netrin-1 upregulation in a majority of human endometrial carcinomas (ECs) and demonstrate that netr...

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Archive ouverte | Pastushenko, Ievgenia | CCSD

International audience. FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initia...

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