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IFN signaling after proton and carbon ion irradiation is enhanced by ATR inhibition

Archive ouverte | Rødland, Gro Elise | CCSD

International audience. BackgroundExternal beam irradiation with x-rays is part of the standard treatment for glioblastoma, but is limited by tumor radioresistance and damage to the normal brain. A lower radiation d...

Potential Benefits of Combining Proton or Carbon Ion Therapy with DNA Damage Repair Inhibitors

Archive ouverte | Rødland, Gro Elise | CCSD

International audience. The use of charged particle radiotherapy is currently increasing, but combination therapy with DNA repair inhibitors remains to be exploited in the clinic. The high-linear energy transfer (LE...

Atr kinase inhibitor augments ifn signaling following proton and carbon ion irradiation

Archive ouverte | Savu, Diana Iulia. | CCSD

International audience. Conventional radiotherapy (X-ray irradiation) plays a crucial role in glioblastoma standard treatment, but is limited by tumor radioresistance and damage to the normal brain. The treatment wi...

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